[Brain] Researchers employed high-dimensional mass cytometry, single-cell RNA-sequencing, ex vivo T cell secretome analysis, and antigen presentation assays to achieve a comprehensive characterization of adaptive immune cell populations.

[Cancer Research] Scientists showed that delivery of only four synthetic guide RNAs with Cas9 endonuclease efficiently induced simultaneous DNA double-strand breaks, resulting in efficient cell death in a cell-type-specific manner.

[JAMA Oncology] Investigators suggested that given both treatment-related harms and benefits, immune checkpoint inhibitor (ICI) + chemotherapy use in the first SACT setting requires informed decision-making; the potential benefits of ICI + chemotherapy vs single ICI in high-risk subgroups is encouraging.

[Cancer Immunology Research] The authors identified cell interactions that predicted progression including increased frequency of CD8⁺ exhausted T cells and stromal cells and decreased frequency of CD56bright NK cells and plasmacytoid dendritic cells.

[Journal of Experimental Medicine] Investigators demonstrated that ZC3H12A deficiency initiates a stemness program in TCF1+ precursor-exhausted T cells (T_PEX) but also increases cell death, whereas BCOR deficiency predominantly promotes T_PEX proliferation.

[Cancer Research] Researchers sought to uncover additional immune checkpoint proteins regulated by the integrated stress response to elucidate mechanisms of tumor immune escape.

[Nature Communications] Investigators described the Epigraph, a computationally derived and epitope optimized set of vaccine immunogens.

[Experimental & Molecular Medicine] Researchers found that P. gingivalis infection notably activates multiple death pathways in bone-marrow-derived macrophages, including pyroptosis, apoptosis, and necrosis.

[ACS Nano ] Scientists presented the self-assembly of nanogold triplets on trimeric viral surface proteins for a sensitive colorimetric assay to identify viruses.

[Science Immunology] Investigators used longitudinal single-cell RNA and T cell receptor tracking to study the functional stability and memory potential of CD4⁺ T cell clonotypes during repeated Plasmodium falciparum infections in Ugandan children and adults.

[Vaccine] Researchers investigated the breadth and cross-subtype immunity of these chimeric cirus-like particles in BALB/c mice to assess their potential for human use.

[Communications Biology] Scientists explored the use of protective small antibodies for the development of transgenic mosquito-based arboviral disease control strategies.