[Telomir Pharmaceuticals, Inc. ] Telomir Pharmaceuticals, Inc. reported new preclinical data from an in vivo study in mice bearing human aggressive prostate cancer tumors evaluating DNA-methylation changes in two key defense genes - CASP8 and GSTP1 - following treatment with oral Telomir-1, Rapamycin, chemotherapy, and combination regimens.

[PCF] The Prostate Cancer Foundation (PCF) announced the first-ever recipient of the PCF Women in Science Lifetime Achievement Award, Maha Hussain, MD, FACP, FASCO, the Genevieve Teuton Professor of Medicine at Northwestern University Feinberg School of Medicine.

[Advanced Science] Scientists developed a small-molecule ZDHHC2 inhibitor, TTZ1, which restores ACSL4 protein, reactivates ferroptosis, and reverses enzalutamide resistance in CRPC cell lines and patient-derived xenograft models.

[Nature Biomedical Engineering] Researchers showed that collagen-binding domain-fused IL-12 secreted from CAR-T cells to target human six transmembrane epithelial antigen of prostate 1 (STEAP1) is retained within murine prostate tumors.

[Experimental Hematology & Oncology] Researchers analyzed the impact of pitavastatin on TNBC cells was assessed in vitro by examining cell viability, apoptosis, mitochondrial function, and effects on cancer stem cell properties.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists evaluated 136 families for coinheritance of breast cancer with each of 79 common variants reported as high-confidence “risk alleles” for breast cancer by meta-analyses of genome-wide association studies.

[Nature] Scientists showed that mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors. In preclinical models, SARS-CoV-2 mRNA vaccines led to a substantial increase in type I interferon, enabling innate immune cells to prime CD8⁺ T cells that target tumour-associated antigens.

[Immunology] Researchers observed that Acr1 skews the differentiation of dendritic cells into functionally competent myeloid-derived suppressor cells that chiefly secrete immunosuppressive molecules, expand regulatory T cells and attenuate inflammatory responses.

[Military Medical Research] The authors explore the advancements in diverse tuberculosis immunotherapeutic strategies, including efficacy, safety, and administration methods.

[Nature Communications] Scientists determined the spatial-localization of M. tuberculosis inside macrophages with reference to the nucleus. Few M. tuberculosis cells are perinuclear, while most are peripheral.

[Nature Communications] Investigators found that macrophages with high oxidative phosphorylation and low glycolysis harbor reductive, drug-tolerant Mycobacterium tuberculosis (Mtb), whereas glycolytically active macrophages generate mitochondrial ROS via reverse electron transport, imposing oxidative stress on Mtb and enhancing drug efficacy.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the early stages of Japanese encephalitis virus infection in the mouse brain employing a highly multiplexed spatial transcriptomics platform to map viral RNA and host gene expressions in intact brain sections at a single-cell resolution.