[Nature Communications] Researchers identified oral-facial-digital syndrome 1 protein (OFD1) as a positive regulator of BRCA1 in human pancreatic cancer cells and specimens, with its overexpression correlating with poor prognosis.

[Molecular cancer] With the help of new glycosylation signatures identified and techniques that allow scientists to reach single-cell resolution, they can target glycans and generate strategies to activate the immune system against PDAC.

[Cancer Discovery] Researchers identified PYK2 as an immunomechanical checkpoint that drives monocyte-to-macrophage differentiation in PDAC via PIEZO1/integrin-mediated mechanical cues.

[Cancer Discovery] Investigators showed that combining a RAS(ON) multi-selective inhibitor with the CDK4/6 inhibitor palbociclib drives persister cells into a senescent-like state, which coincides with improved tumor control and substantial remodeling of the tumor microenvironment.

[Nature Communications] Researchers identified March5 and Trim28 as key modulators of β-cell function. March5 is downregulated and Trim28 upregulated in islets from human or mouse with impaired glucose tolerance.

[Oncolytics Biotech^®, Inc.] Oncolytics Biotech^® Inc. announced it has initiated regulatory discussions with the US FDA for a potential registration-enabled pivotal study in first-line metastatic PDAC.

[Circulation Research] Scientists used single-cell RNA sequencing and spatial transcriptomics to identify endothelial cell states after acute myocardial infarction in mice.

[Arteriosclerosis Thrombosis and Vascular Biology] The authors investigated ascending aortic aneurysm initiation by assessing the relation between aortic regurgitation and vascular activation and inflammation.

[Cancer Letters] Scientists established a single-cell atlas of endothelial cells (ECs) in gastric cancer and identified a subpopulation of COL1A1⁺ ECs that play a critical role in tumor progression and metastasis.

[Salk Institute] Salk Institute Professor Diana Hargreaves was named a 2025 All-Star Translational Award Program grantee by the V Foundation for Cancer Research.

[Oncoimmunology] The authors analyzed single-cell sequencing datasets and clinical specimens to evaluate the role of focal adhesion kinase (FAK) in the immune response of pancreatic cancer.

[Diabetes] Investigators developed a whole-slide scanned image analysis pipeline for semiautomated quantitation of endocrine area, islet frequency, interislet distance, and endocrine object size distribution.