Keep Current with the Latest in Cell Biology Research

Midkine Promotes Renal Fibrosis by Stabilizing C/EBPβ to Facilitate Endothelial-Mesenchymal Transition

[Communications Biology] Investigators demonstrated Midkine mainly expressed by CD31 + ACTA2+ECs going through partial EndMT contributed greatly to myofibroblasts by spatial and single-cell transcriptomics.

Mechanical Properties, Collagen and Glycosaminoglycan Content of Equine Superficial Digital Flexor Tendons Are Not Affected by Training

[Journal Of Anatomy] Scientists investigated whether different training histories of horses would influence the synthesis of collagen and other matrix proteins and alter the mechanical properties of tendon.

Synergistic Effects of Matrix Biophysical Properties on Gastric Cancer Cell Behavior via Integrin-Mediated Cell-ECM Interactions

[Small] By combining collagen I and alginate, researchers designed an in vitro biomimetic hydrogel platform to independently modulate matrix stiffness and structure across a physiological stiffness spectrum while preserving consistent collagen concentration and fiber topography.

ARID1B Controls Transcriptional Programs of Axon Projection in an Organoid Model of the Human Corpus Callosum

[Cell Stem Cell] Researchers found that neurons expressing SATB2, a determinant of callosal projection neuron (CPN) identity, show impaired maturation in ARID1B+/− neural organoids.

Cerebral Organoids Display Dynamic Clonal Growth and Tunable Tissue Replenishment

[Nature Cell Biology] Investigators implemented whole-tissue lineage tracing by genomic DNA barcoding in 3D human cerebral organoids, to show that individual stem cell clones produced progeny on a vastly variable scale.

The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance

[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, investigators identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.

Thymocyte Migration and Emigration

[Immunology Letters] Investigators review the contribution of the key factors mentioned above for the localization, migration and emigration of thymocytes.

Traverse Biotech Awarded Phase I SBIR Grant by the National Institute of Allergy and Infectious Diseases for Development of Innate Immune Stimulator

[Traverse Biotech, Inc. (PR Newswire)] Traverse Biotech, Inc. has been awarded a Phase I Small Business Innovation Research grant from the National Institute of Allergy and Infectious Diseases, part of the NIH.

Optimisation of a Primary Human CAR-NK Cell Manufacturing Pipeline

[Clinical & Translational Immunology] Scientists developed an optimised expansion and transduction protocol for primary human NK cells primed for manufacturing scaling and clinical evaluation.

Multi-Omics Analysis of Human Tendon Adhesion Reveals That ACKR1-Regulated Macrophage Migration Is Involved in Regeneration

[Bone Research] Scientists found that SPP1+ macrophages, RGCC+ endothelial cells, ACKR1+ endothelial cells and ADAM12+ fibroblasts participated in tendon adhesion formation.

Aging-Regulated PNUTS Maintains Endothelial Barrier Function via SEMA3B Suppression

[Communications Biology] Investigators determined the role of Phosphatase 1 Nuclear Targeting Subunit (PNUTS) in endothelial cell aging. They confirmed that PNUTS was repressed in senescent endothelial cells.

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings from a Randomized Controlled Study

[Journal Of The American Heart Association] The authors examined the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health.

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