[Journal Of Clinical Investigation] The authors investigated whether satellite cells could be derived in allogeneic or xenogeneic animal hosts.

[Journal Of Clinical Investigation] Scientists showed that the pathogenic SRSF2P95H/+ mutation disrupted the splicing of mitochondrial mRNAs, impaired mitochondrial complex I function, and robustly increased mitophagy.

[Cell Metabolism] Researchers demonstrated that cytochrome b (CYTB) also encoded an unrecognized 187-amino-acid-long protein, CYTB-187AA, using the standard genetic code of cytosolic ribosomes rather than the mitochondrial genetic code.

[Journal of Cell Biology] Investigators revealed the mechanism of heterochromatin targeting of histone H3 lysine36 dimethylation (H3K36me2). Among several H3K36 methyltransferases, NSD2 was responsible for inducing heterochromatic H3K36me2.

[Stem Cell Reports] Scientists investigated the role of zinc finger ZZ-type containing 3 (ZZZ3) in human ESCs homeostasis. They found that knockdown of ZZZ3 negatively impacted ribosome biogenesis, translation, and mTOR signaling, leading to a significant reduction in cell proliferation.

[NAR Genomics and Bioinformatics] Researchers performed a nuclear knockdown of Malat1 in mESCs, causing the de-regulation of 320 genes and aberrant splicing of 90 transcripts, some of which potentially affecting the translated protein sequence.

[Trends in Cell Biology] Investigators provide a comprehensive assessment of published forward programming protocols that are based on forced expression of key lineage transcription factors.

[MIT Technology Review] The experiment, at the University of Florida, is an attempt to create a large animal starting only from stem cells—no egg, no sperm, and no conception.

[Cell Reports Medicine] Scientists presented prime editing approaches to correct L227R- and N1303K-CFTR, two mutations that caused cystic fibrosis and were not eligible for current market-approved modulator therapies.

[Biomaterials Advances] Decellularized extracellular matrix-derived from sheep muscle tendon junction (MTJ) was used to provide a scaffold for the MTJ with the relevant mechanical properties and differentiation cues such as the relase of growth factors.

[Hesperos, Inc.] Hesperos was awarded a $2 million research grant by the National Center for Advancing Translational Sciences in collaboration with the US FDA. The goal of the effort is to develop an advanced testing platform capable of assessing the potency of the Botulinum Toxin without the need for animal testing.

[Stem Cell Research & Therapy] To manufacture hematopoietic organoids, researchers obtained CD34+ hematopoietic stem and progenitor cells from human embryonic stem cells using stepwise induction and immunomagnetic bead-sorting.