[Cell Stem Cell] Investigators demonstrated that mouse naive ESCs and naive iPSCs can be simultaneously co-induced to generate primitive endoderm and trophectoderm extra-embryonic cells that self-organize into embryonic day 8.5–8.75 transgene-free stem cell-derived mouse embryo models.

[MetaVia] MetaVia Inc. announced a research collaboration with Syntekabio, Inc. to identify additional disease targets and optimize the therapeutic profile of DA-1241, MetaVia's novel oral G-Protein-Coupled Receptor 119 agonist.

[Stem Cell Reports] Investigators revealed that promyelocytic leukemia protein (PML)-deficient cells exhibited increased mTOR pathway activation and protein translation, as well as impaired autophagy and proteasome activity, resulting in increased formation of aggregates and stress-induced death.

[Cellular & Molecular Immunology] Researchers identified CD4⁺Notch2⁺Foxp3^lo T cells in the spinal cords of mice with experimental autoimmune encephalomyelitis, dextran sodium sulfate−induced colitis model mice, and patients with ulcerative colitis as immune regulatory cells.

[ACS Nano] In vivo experiments demonstrated that the clinical score of collagen-induced arthritis mice treated with the mZPMG nanoparticles was 72.92% lower than those treated with phosphate buffered saline.

[Biomaterials] Scientists reported that β-amyloid 1–42 antigen-specific CD4⁺ T cells spontaneously cross the blood-brain barrier (BBB) into the brain in an APP/PS1 mouse model.

[Genome Medicine] Investigators highlighted the crucial role of CXCR4 in deriving T_reg-mediated immunosuppression via regulating the Rho-GTPase/NF-κB signaling axis, informing the potential of combining CXCR4 blockades with T cell-targeted immunotherapies.

[Cancer Research] Researchers investigated the anti-tumor potential of lipid nanoparticle-encapsulated mRNA encoding the tumor-specific toxin protein neutrophil elastase.

[Leukemia] Researchers highlighted the key to understanding the cell origin of adult T-cell leukemia/lymphoma and developing unprecedented therapeutic strategies for refractory diseases.

[Journal of Translational Medicine] Investigators identified glycerol-3-phosphate dehydrogenase 1-like (GPD1L) as a tumor suppressor gene in clear cell renal cell carcinoma (ccRCC), and downregulation of GPD1L may facilitate the adaptive survival of tumor cells via enhanced Tregs infiltration and lipid metabolism reprogramming in ccRCC.

[Journal of Medicinal Chemistry] Scientists discovered a small molecule inhibitor, KBD4466, which demonstrated excellent cellular activity, favorable pharmacokinetic properties, potent inhibition of cytokine production in mouse pharmacodynamic studies, and outstanding therapeutic efficacy in an systemic lupus erythematosus animal model.

[Autoimmunity] Scientists investigated the role of carboxypeptidase N subunit 2 (CPN2) in modulating immune activation and testicular pathology via the NF-κB signaling pathway.