[Applied Biochemistry And Biotechnology] A bacterial EPS from the marine bacterium Halomonas malpeensis YU-PRIM-29T was used to treat the burn wound in vivo. In vitro biocompatibility of EPS-H29 was studied in human dermal fibroblasts and keratinocytes.

[Communications Biology] Investigators reported that Dab2 conditional knockout mice exhibited a delay in the hair follicle cycle due to perturbed activation of hair follicle stem cells.

[Nature Communications] Using lineage tracing studies along with transcriptomic characterization, scientists demonstrated that treatment of adult mice with a small molecule that inhibits kinase activity of focal adhesion kinase resulted in trans-differentiation of a subset of peri-islet acinar cells into insulin producing β-like cells.

[Diabetes Obesity & Metabolism] Genetic animal models and transgenic immortalized cells were applied to study the effect of adenosine kinase on islet beta-cell proliferation and function.

[Advanced Materials] Black phosphorus nanosheets (BPNSs) interacted directly with α-synuclein (α-syn) fibrils to trigger their disaggregation for Parkinson's disease treatment. BPNSs were found to activate autophagy to maintain α-syn homeostasis, improve mitochondrial dysfunction, reduce reactive oxygen species levels, and rescue neuronal death and synaptic loss in PC12 cells.

[Brain] Correlative light and electron microscopy were employed to investigate alpha-synuclein pathology in the substantia nigra and putamen of post-mortem multiple system atrophy brain donors.

[Journal Of Cell Biology] Scientists demonstrated that sleep induced microglia-dependent synaptic enrichment of GABAARs in a manner dependent on microglial TNFα and P2RX7.

[Molecular Biology Reports] The antiproliferative effects of 5-fluorouracil and doxorubicin were investigated separately and in combination using 2D and 3D cell culture models on two different colon cancer cell lines.

[Clinical Cancer Research] Scientists assessed proof-of-mechanism and clinical feasibility for Sacituzumab govitecan (SG) and talazoparib employing an innovative sequential dosing schedule. In vitro, sequential SG followed by talazoparib delayed topoisomerase 1 cleavage complex clearance, increased DNA damage and promoted apoptosis.

[Cell Death & Disease] Scientists discovered that argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, directly bound to phosphoglycerate dehydrogenase (PHGDH) and promoted its ubiquitination-mediated degradation to inhibit serine synthesis, consequently suppressing tumorigenesis.

[Molecular Psychiatry] The authors reported a point mutation on SHANK2, which was found in a patient with autism. This mutation resulted in an early stop codon and an aberrant splicing event that impacted SHANK2 transcript variants distinctly. iPSCs carrying this mutation failed to differentiate into functional dopamine neurons.

[Cell Death Discovery] Researchers analyzed the prognostic value and clinical significance of serpin family a member 1 (SERPINA1) in colorectal cancer, and predicted potential transcription factors.