[Nature Communications] Researchers revealed that both genetic and pharmacological inhibition of mono-ADP-ribosyl hydrolase MacroD1 alleviates myocardial metabolic impairment, inflammation, dysfunction, and the risk of mortality caused by lipopolysaccharide and cecal ligation and puncture.

[Advanced Science] Scientists observed that muscle-specific ribosomal protein S27-like (Rps27l) knock-in mice exhibit significantly increased muscle mass, enlarged myofiber size, a higher proportion of fast-twitch myofibers, and enhanced muscle regeneration capabilities compared to wild-type controls.

[Diabetes & Metabolism Journal] Apolipoprotein E-knockout mice were intraperitoneally injected streptozotocin for five days and fed a high-fat diet for 12 weeks for establishing an in vivo diabetic atherosclerosis model.

[Science] Using mouse models supported by human data, the authors determined that resistin-like molecule gamma is highly expressed in neutrophils after myocardial infarction.

[Cancer Research] Using patient-derived organoid models, single-cell RNA sequencing, and multiplex immunofluorescence staining of samples from patients with PDAC, in vivo TGFβ1 conditional knockout mouse models, and 3D in vitro models, scientists discovered that the formation of intratumoral necrotic foci in pancreatic cancer is closely associated with liver metastatic events.

[Science Translational Medicine] Researchers comprehensively evaluated the preclinical efficacy of BI-2493, a first-in-class allele-agnostic mutant-KRAS inhibitor, in PDAC.

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Investigators found that PIM1, a serine/threonine kinase, is upregulated in PDAC tumors and serves as a poor prognostic indicator.

[Cancer Discovery] The authors showed that aryl hydrocarbon receptor ligands found in cigarette smoke, like the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, promote pancreatic dysplasia and PDAC progression in a mouse model of this disease.

[Corstasis Therapeutics (Business Wire)] Corstasis Therapeutics Inc. announced that the US Patent and Trade Office has allowed a new patent for its proprietary subcutaneous bumetanide formulations expanding its pipeline beyond Enbumyst™ into subcutaneous dose forms.

[Cell] Using high-resolution single-cell RNA sequencing, researchers systematically characterized hepatocyte adaptations in mice across pregnancy and postpartum stages.

[Cancer Letters] Analysis of the LIHC-TCGA database and comparisons between HCC tissues and adjacent peri-tumoral tissues revealed that 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4) is significantly upregulated in HBV-associated HCC.

[Cell & Bioscience] Wnt5a protein expression was assessed in liver biopsy tissues from patients with hepatitis B-associated liver fibrosis and cirrhosis was induced in rats using CCl₄/2-AAF.