[Nature] Researchers administered anti-CD47 antibodies in combination with adoptively transferred T cells with the goal of enhancing antitumour efficacy but observed abrogated therapeutic benefit due to rapid macrophage-mediated clearance of T cells expressing CARs or engineered T cell receptors.

[Small] A CAR T cell membrane-camouflaged nanocatalyst (ACSP@TCM) was prepared to augment CAR T cell therapy efficacy against solid tumors. ACSP@TCM was prepared by encapsulating core/shell Au/Cu2-xSe and 3-bromopyruvate with a CAR T cell membrane.

[British Journal Of Cancer] Scientists discuss next-generation sequencing workflows, the structure of next-generation sequencing reports, and our recommendations for best practice thereof.

[Acta Pharmacologica Sinica] The authors generated GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK for the treatment of HCC. GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK specifically and effectively lysed GPC3-positive tumor cells in vitro in an antigen-dependent manner.

[Neuro-Oncology] SMYD2-induced PGC1α methylation and followed nuclear export was confirmed by co-immunoprecipitation, cellular fractionation, and immunofluorescence.

[Journal For Immunotherapy Of Cancer] Researchers designed a bispecific T cell engager capable of cross-linking CD3 on T cells with NKG2DL-expressing GBM cells. They then engineered the G207 virus to express the NKG2D BiTE and secrete it from infected cells.

[Intensity Therapeutics, Inc.] Intensity Therapeutics, Inc. announced that the company executed a collaboration agreement with The Swiss Group for Clinical Cancer Research SAKK to conduct a Phase II randomized, controlled trial evaluating clinical and biological effects of intratumoral INT230-6 followed by the standard of care (SOC) immuno/chemotherapy vs. SOC immune/chemotherapy alone in early-stage triple-negative breast cancer in 54 patients in Switzerland.

[Molecular Biotechnology] BLCA cells were used to investigate the effects of Nup93 overexpression or knockdown on cell growth, invasion, stemness , and Wnt/β-catenin signaling in vitro.

[British Journal Of Cancer] Investigators generated double-knockout mice for CCR1 and CXCR2, and performed bone marrow transfer experiments in which sub-lethally irradiated wild-type mice were reconstituted with bone marrow from either wild-type, Ccr1−/−, Cxcr2−/− or Ccr1−/−Cxcr2−/− mice.

[Scientific Reports] The authors introduced a novel device called the Flexible Unique Generator Unit, which is a unique combination of flexible silicone membranes and solid components made of stainless steel.

[Journal Of Drug Targeting] The authors elaborates on recent advancements of mesenchyma stem cell mediated drug delivery of anti-cancer agents along with its mechanism and previously reported studies of drugs manufactured via this drug delivery system.

[Nature Communications] Investigators employed a culture system specifically established for hepatic progenitor cells to study hepatocyte dedifferentiation.