2024-05-15 | CSCN 13.13 .email-footer a { text-decoration: none !important; } h3 a { text-decoration: none !important; font-weight:...

[Acta Pharmacologica Sinica] Researchers used vascular smooth muscle-specific leucine-rich repeat-containing family 8 A (LRRC8A) knockout mice and an angiotensin II-induced hypertension model.

[Cell] The authors revealed a direct differentiation pathway from HSCs into platelets that is progressively propagated upon aging. The aging-enriched platelet path was decoupled from all other hematopoietic lineages, including erythropoiesis, and operated as an additional layer in parallel with canonical platelet production.

[Cell Stem Cell] Scientists demonstrated that autophagy was an adaptive cytoprotective response to chronic inflammation in the aging murine bone marrow niche.

[Molecular Therapy] Scientists evaluated carbon monoxide (CO)-induced autophagy in human(h) MSCs, and its impact on cell function in murine cecal ligation and puncture.

[Cell Reports] Researchers described the functions of linc-adipose anti-inflammatory (ADAIN), an adipose lincRNA that was downregulated in white adipose tissue of obese humans.

[Genome Research] Investigators showed that microRNA activity, which was otherwise dispensable for preimplantation development, was essential for the adaptation of early mouse embryos to the dormant state of diapause.

[Stem Cells] Researchers used hPSCs which formed compact colonies consisting of dynamically active cells at the periphery and epithelial-like cells at the core.

[Cell Biology International] The authors collated a list of 1141 genes in connection to the term “endocytosis” from Kyoto Encyclopedia of Genes and Genomes and Gene Ontology and examined the effect of their knockdown on the pluripotency of mESCs using levels of green fluorescent protein driven by the Oct4 promoter.

[Cell] Investigators performed prospective lineage tracing of human embryos using live imaging, non-invasive cell labeling, and computational predictions to determine the contribution of each 2-cell stage blastomere to the epiblast, hypoblast, and trophectoderm.

[Development] Scientists describe the similarities and differences of the expression pattern in space and in time of mammalian Hes/zebrafish Her genes and their targets in different tissues.

[Maryland Stem Cell Research Commission] The Maryland Stem Cell Research Commission announced the next round of awards granting a total of more than $15.4 million. These awards are aimed at fostering groundbreaking research to enhance and propel stem cell treatments and technologies across Maryland.