[Blood] Scientists performed a genome-wide CRISPR knockout screen in primary mouse hematopoietic stem and progenitor cells to discover novel regulators of ex vivo expansion. The screen identified Runx2 as a strong negative regulator of HSC expansion.

[Leukemia] Researchers developed a novel humanized model using CRISPR/Cas9 technology to knock-in GATA2-R398W variant in primary cord blood CD34^⁺ cells.

[Science Advances] Bulk whole-genome sequencing of 637 matched tumor-normal samples from the Pediatric Cancer Genome Project revealed an enrichment of functionally impactful mitochondrial DNA variants in specific pediatric leukemia subtypes.

[Blood] Researchers showed that the mitochondrial protease caseinolytic peptidase P (ClpP) is both a cell-intrinsic metabolic vulnerability and an actionable immunogenic trigger in multiple myeloma.

[Blood] Investigators showed that genetic inactivation of additional sex combs like 1 and enhancer of zeste homolog 2 in murine hematopoietic stem/progenitor cells results in highly penetrant hematological malignancies as observed in corresponding human diseases.

[Molecular and Cellular Biology] The authors summarize the current understanding of the mechanisms by which iron imbalance contributes to erythropoietic failure and highlight BACH1 as a potential integrative regulator in the pathophysiology of anemia in both iron-overload and iron-deficient states.

[Nature] Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

[Virulence] The authors explore the biosynthesis and regulation of enterobactin, highlighting its contribution to bacterial pathogenesis and immune evasion

[iScience] Researchers investigated the ability of primary plasmacytoid pre-dendritic cells, type 2 dendritic cells, and monocytes isolated from healthy donors to respond to SARS-CoV-2 variants.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists conducted proteomic analysis of a clinical human cytomegalovirus strain virion. This revealed 18 novel components, including the viral protein gpUL141, which is recognized as an NK immune-evasin that targets several host proteins when expressed within the cell.

[Nature] Investigators show how myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, thereby facilitating neutrophil extracellular traps (NETs) formation, yet also binds stably to NETs extracellularly.

[Nature Genetics] Researchers tested >18,000 autoimmune disease-associated variants for allele-specific effects on expression using massively parallel reporter assays in primary human CD4⁺ T cells.