[Science] Scientists examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, they created a basic clock module involving a central and a peripheral clock.

[Parent Project Muscular Dystrophy (PPMD)] PPMD announced a $250,000 award to Bo Hoon Lee, MD, from the University of Rochester to support the development of a clinical research network for Duchenne babies identified through newborn screening efforts in New York State.

[Journal of Cellular and Molecular Medicine] Researchers analyzed a large group of patients with NPM1mutated AML enrolled in prospective trials to delineate the impact of baseline molecular and clinical features, post induction measurable residual disease status and treatment intensity on outcome.

[Cell Death Discovery] The authors showed that miRNA-7145, a miRNA with previously unknown function, was enriched in erythrocytes at the definitive wave, but not expressed in myeloid cells.

[Bone Research] The authors elucidate the structure of pannexins and their roles in regulating processes such as osteogenesis, chondrogenesis, and muscle growth.

[Scientific Reports] Integrative analyses of multiple-omics data revealed that high mobility group nucleosome binding (HMGN) frequently exhibit dysregulation in lung adenocarcinoma (LUAD). Subsequent analysis of the clinical relevance of HMGN1 demonstrated its association with poor prognosis in LUAD and its potential as a diagnostic marker to differentiate LUAD from healthy controls.

[Acta Pharmacologica Sinica] The authors reported the identification, optimization, and evaluation of 1,2,3,4-tetrahydroquinoline derivatives as novel RORγ inverse agonists, starting from high throughput screening using a thermal stability shift assay.

[Scientific Reports] Scientists used previously characterized Epstein-Barr virus (EBV)-PCR-positive and EBV-negative prostate carcinoma (PCa) tissues to perform an IHC-based assessment of key histopathological and molecular markers of PCa aggressiveness

[Blood Cancer Journal] Long-term EBMT registry data were used to provide large scale, up-to-date outcome results and to identify factors for improved outcome

[Neuron] Scientists detailed the safe application of anti-CD19 CAR T cells for treating concomitant MG/LEMS. After CAR T cell therapy, both patients experienced rapid clinical recovery and regained full mobility.

[Bioactive Materials] The authors introduce strategies based on biomaterial-assisted Treg immunotherapy to enhance transplant medicine and autoimmune treatments.

[Acta Biomaterialia] Investigators discuss existing treatment strategies following muscle damage, recent progress in bioprinting techniques, the bioinks used for muscle regeneration, the immunogenicity of scaffold materials, and in vitro and in vivo maturation techniques for 3D bio-printed muscle constructs.