[University of Miami Miller School of Medicine (EurekAlert!)] Patients in South Florida with metastatic melanoma will soon have access to tumor-infiltrating lymphocyte therapy, following its recent approval by the FDA. It will be available to patients at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.

[iScience] The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.

[Scientific Reports] Scientists designed and evaluated targeted carbon nanotubes containing curcumin, and assessed their in vitro cytotoxicity effects on melanoma cancer cells.

[Nature Communications] The authors reported that galectin-3, mainly produced and secreted by macrophages, was elevated in islets from both high-fat diet-fed and diabetic mice.

[Journal Of Diabetes Investigation] The authors outline the processes of β-cell failure and detail the many β-cell abnormalities that manifest in people with diabetes mellitus.

[Journal Of Mammary Gland Biology And Neoplasia] Investigators described a normal breast explant model utilising a tuneable hydrogel which maintained epithelial proliferation, hormone receptor expression, and residency of T cells and macrophages over seven days.

[Biotechnology and Applied Biochemistry] The authors investigated the effects of miR-99a and miR-143 in single expression plasmids for breast cancer (BC) inhibition. Upregulation of miR-99a and miR-143 in any of the two selected BC cells inhibited their proliferation and migration rate, and induced apoptosis.

[Cell Communication and Signaling] Using preclinical models of spontaneous breast cancer metastasis, scientists investigated the impact of SMAD4 on the ability of bone morphogenetic protein 4 (BMP4) to regulate tumor growth and metastasis.

[Cancer Discovery] Scientists identified a subset of myofibroblast cancer-associated fibroblast (CAFs) that were senescent (senCAF) in mouse and human breast tumors. SenCAFs were present in HER2+, ER+, and triple-negative breast cancer and in ductal carcinoma in situ (DCIS) where they predicted tumor recurrence.

[Discover Oncology] The authors provide insights into the mechanism of exosome-derived non-coding RNAs (ncRNAs) in breast cancer (BC) drug resistance, thereby suggesting new strategies for the treatment of BC.

[Monash University] Two research projects on different aspects of breast cancer treatment led by Monash Biomedicine Discovery Institute researchers, Drs. Lan Nguyen and Thierry Jardé have been awarded a total of almost $1.5 milion by the National Breast Cancer Foundation.

[Nature Communications] Scientists examined the epigenomic profiles of more than 500 cell cultures of iPSC-derived motor neurons generated from ALS patients and healthy controls to test for the presence of genetically driven, disease-relevant changes in chromatin accessibility and dysregulated transcriptional programs.