[Blood] Scientists elucidated the molecular architecture and kinetics preceding AML relapse by utilizing error-corrected next-generation sequencing in 74 AML patients relapsing after alloHCT evaluating 140 samples from peripheral blood collected 0.6 to 14 months before relapse.

[Blood] Investigators performed a retrospective multicenter study via the EBMT registry on 306 children with IEI undergoing first transplant between 2010-2019 from an HLA-mismatched donor using TCRαβ or PTCY.

[Nature News] Surgeons in Japan have transplanted kidney tissue from one rat fetus to another, while the recipient was still in its mother's womb. Study lead Takashi Yokoo, a nephrologist at Jikei University School of Medicine in Tokyo, says the surgery is the first step to one day transplanting fetal pig kidneys into human fetuses that develop without functioning kidneys.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers described the nanoplatform for interrogating living cell host-gene and (micro-)environment relationships, that integrates micro- and nanofluidics to enable highly efficient capture of circulating tumor cells from blood samples.

[Nature Cancer] The authors review how the circadian clock influences CSCs and their local tumor niches in the context of different stages of tumor metastasis.

[Cell Death & Disease] The authors observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in lung adenocarcinoma cells when grown in 2D conditions; however, when grown in 3D conditions, all cell lines underwent a phenotypic switch, exhibiting substantial resistance to RSL3 and, therefore, protection against ferroptotic cell death.

[Scientific Reports] As a proof-of-concept, investigators established a 3D culture of gelatin-methacryloyl-encapsulated mesenchymal stem/stromal cells.

[BMC Cancer] Through bioinformatics analysis, researchers discovered a previously unstudied differential gene called HIST3H2A in prostate cancer (PCa). They revealed that HIST3H2A was highly expressed in PCa tissues, as confirmed by analysis of both the GEO and UALCAN databases.

[British Journal of Pharmacology] Human fibrocytes were isolated from peripheral blood of six healthy donors. Recombinant human (rh)-IL-11 and soluble rh-IL-11 receptor, α subunit were used to stimulated fibrocytes in vitro to measure cell migration in a chemotactic migration chamber among other variables.

[Journal of Cancer Research and Clinical Oncology] The core 1β1,3-galactosyltransferase 1 (C1GALT1) expression and its clinical relevance were investigated through public databases and lung adenocarcinoma tissue microarray analyses.

[Biology Open] The authors showed that serine/arginine repetitive matrix 2 (Srrm2) dosage was critical for maintaining ESC pluripotency and cell identity.

[Stem Cell Research & Therapy] Investigators review the progress of haploid ESC research and briefly discuss the applications of haploid ESCs.