[Nature Biotechnology] The authors described a clinically guided method to differentiate and expand IL-15-enhanced allogeneic CAR-NKT cells with high yield and purity.

[Cell Discovery] Investigators reported newly developed anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies (bNAbs) and the follicle-homing receptor CXCR5, termed M10 cells.

[Cancer Science] The authors show edthat CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.

[Scientific Reports] Investigators isolated exosomes (Exos) from MSCs, and using probe-sonication approach loaded them with vincristine (VCR) sulfate. Using SRB assay, the cytotoxicity of VCR sulfate-Exo was assessed in T47D breast cancer cells, and the results were contrasted with those of free VCR sulfate.

[Advanced Healthcare Materials] The authors explored current limitations to in vitro organ morphogenesis, emphasizing the interplay of gene regulatory networks, mechanical factors, and tissue microenvironment cues.

[Scientific Reports] The authors validated the utility of serum LOXL2 levels as a predictive biomarker for the development of HCC in patients with hepatitis C virus infection who achieved a sustained virological response.

[Cell Reports Methods] The authors used human adipose stromal/stem cells to construct hepatic organoids and treated them with ethanol to simulate alcohol-associated liver disease in vitro.

[Cell Death Discovery] In vivo and in vitro experiments were performed to verify the promoting effects of IL-17a administration, IL-17a overexpression, and FAP upregulation in HSCs on liver fibrosis and liver tumorigenesis.

[Cardiovascular Research] Researchers observed a reduction in transducin beta-like protein 1 (TBL1) protein expression levels as well as cleavage events in the transplanted cardiac tissues of patients diagnosed with dilated cardiomyopathy and doxorubicin-induced cardiotoxicity.

[Journal Of Cachexia Sarcopenia And Muscle] The authors used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U-13C6]glucose tracer.

[Leukemia] Scientists generated a BCR::ABL1 conditional knock-in (KI) mouse model, which developed aggressive myeloid leukemia, and demonstrated that the deletion of the Tif1β gene inhibited the progression of myeloid leukemia and showed longer survival than that in BCR::ABL1 KI mice

[Cell Reports] The authors demonstrated that CUT-like homeobox 1 (CUX1) directed the BAF chromatin remodeling complex to DNA to increase chromatin accessibility in hematopoietic cells.