[Molecular Therapy] Using mouse models of acute lymphoblastic leukemia (ALL), renal cell carcinoma (RCC), and glioblastoma (GBM), we show that enforced expression of the glucose transporter GLUT1 enhances anti-tumor efficacy and promotes favorable CAR T cell phenotypes for two clinically relevant CAR designs, 19-28z and IL13Rα2-BBz.

[Molecular Therapy] Investigators evaluated the efficacy of CAR T cell-mediated cancer cell lysis potential in the immune microenvironment of Branched Chain Amino Acids supplementation and deletion.

[Nature Cancer] Researchers examined the role of microglia using mouse models and cohorts of individuals with ICANS. CD19-directed CAR (CAR19) T cell transfer in B cell lymphoma-bearing mice caused microglia activation and neurocognitive deficits.

[International Journal Of Oral Science] The authors demonstrated that human dental pulp stem cells mediated oxidative stress improvement and neuroreparative effects in in vitro Alzheimer’s disease models, playing critical roles in regulating the polarization of hyperreactive microglia cells and the recovery of damaged neurons.

[Cell] Researchers created “onion-like” multi-lamellar RNA lipid particle aggregates to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens.

[Journal For Immunotherapy Of Cancer] Scientists implemented a one-shot approach to prevent rejection of engineered T cells by simultaneously reducing antigen presentation and the surface expression of both Classes of the major histocompatibility complex (MHC) via expression of the viral inhibitors of transporter associated with antigen processing in combination with a transgene coding for shRNA targeting class II MHC transactivator.

[Advanced Science] To explore cell fate changes of human brain organoids before and after transplantation, human brain organoids are transplanted into prefrontal cortex and hippocampus, respectively.

[Haematologica] Scientists performed a retrospective analysis of 240 patients with relapsed/refractory large B-cell lymphoma treated with standard-of-care axicabtagene ciloleucel (and identified 40 patients (16.7%) who had delay in axi-cel infusion.

[Stem Cell Research & Therapy] Although stem cell-based models and therapies for Alzheimer’s disease (AD) face several challenges, such as extended culture time and low differentiation efficiency, they still show considerable potential for AD treatment and are likely to become preferred tools for AD research.

[Journal Of Translational Medicine] A logical framework for thinking about mechanism of action, potency and efficacy is presented that is consistent with the existing regulatory guidelines, but also accommodates what has been learned from the 27 US FDA-approved cell therapy products.

[Angiogenesis] Scientists hypothesized that chemokine C-C motif ligands 4 (CCL4) might play a vital role in aging-related vascular dysfunction. Circulating CCL4 was up-regulated in elderly subjects and in aged animals.

[Nanoscale] Researchers engineered sub-100 sized nanomicelles targeting proliferation and angiogenesis using an esterase-sensitive phosphocholine-tethered docetaxel conjugate of lithocholic acid (LCA) and a poly(ethylene glycol) derivative of an LCA–combretastatin A4 conjugate.