Keep Current with the Latest in Cell Biology Research

Optimisation of a Primary Human CAR-NK Cell Manufacturing Pipeline

[Clinical & Translational Immunology] Scientists developed an optimised expansion and transduction protocol for primary human NK cells primed for manufacturing scaling and clinical evaluation.

Multi-Omics Analysis of Human Tendon Adhesion Reveals That ACKR1-Regulated Macrophage Migration Is Involved in Regeneration

[Bone Research] Scientists found that SPP1+ macrophages, RGCC+ endothelial cells, ACKR1+ endothelial cells and ADAM12+ fibroblasts participated in tendon adhesion formation.

Aging-Regulated PNUTS Maintains Endothelial Barrier Function via SEMA3B Suppression

[Communications Biology] Investigators determined the role of Phosphatase 1 Nuclear Targeting Subunit (PNUTS) in endothelial cell aging. They confirmed that PNUTS was repressed in senescent endothelial cells.

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings from a Randomized Controlled Study

[Journal Of The American Heart Association] The authors examined the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health.

New $2 Million Research Initiative Will Study Heart and Brain Health in People With Autism

[American Heart Association] According to the US Centers for Disease Control and Prevention, 1 in 36 children and 1 in 45 adults in the US have autism, a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication.

BTK Drives Neutrophil Activation for Sterilizing Antifungal Immunity

[Journal Of Clinical Investigation] Upon fungal exposure, BTK was activated in human neutrophils in a TLR2-, Dectin-1-, and FcγR-dependent manner, triggering the oxidative burst.

Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics

[Ophthalmology] Researchers investigated the effect of seasonal-driven environmental factors on the density, morphology, and dynamic behavior of human corneal immune cell subsets.

Pan-Cancer Analysis of Prognostic and Immunological Role of IL4I1 in Human Tumors: A Bulk Omics Research and Single Cell Sequencing Validation

[Discover Oncology] IL4I1 was significantly overexpressed in the majority of tumors, and the imbalance of IL4I1 was significantly correlated with overall survival and pathological stage. Moreover, total IL4I1 protein was increased in cancer.

T Cell Expression of CXCL13 Is Associated with Immunotherapy Response in a Sex-Dependent Manner in Patients with Lung Cancer

[Cancer Immunology Research] The authors investigated differences in T cell responses between male and female patients with lung cancer by performing sex-based analysis of single cell transcriptomic datasets.

PGRN Is Involved in Macrophage M2 Polarization Regulation through TNFR2 in Periodontitis

[Journal Of Translational Medicine] Immunohistochemical and multiplex immunohistochemical stainings were performed to evaluate the expression of macrophage-related markers and progranulin (PGRN) in gingival samples from periodontally healthy subjects and periodontitis subjects.

Israeli Researchers Measure Interaction Between Immune Cells and Cancer Cells

[The Jerusalem Post] A new technology developed at Bar-Ilan University in Ramat Gan and funded by the Israel Cancer Association will help oncologists and other medical professionals to determine the best way to help patients.

Traverse Biotech Awarded Phase I SBIR Grant by the National Institute of Allergy and Infectious Diseases for Development of Innate Immune Stimulator

[Traverse Biotech, Inc. (PR Newswire)] Traverse Biotech, Inc. has been awarded a Phase I Small Business Innovation Research grant from the National Institute of Allergy and Infectious Diseases, part of the NIH.

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