[Nature Communications] Investigators presented a strategy for replicating the intricate microenvironment of the intestine by cultivating intestinal cells within bioinspired 3D interfaces that recapitulate the villus-crypt architecture and 3D tissue arrangement of the intestine.

[Cell Death & Disease] Scientists revealed its crucial role in suppressing oncogenic signaling. They demonstrated that pro-NAG-1/GDF15 is predominantly retained within cells, whereas its mature form is secreted into the media.

[Cell Death Discovery] Flow cytometry was used to assess special AT-rich sequence-binding protein 2 (SATB2)’s role in colonic epithelial repair in a radiation injury model. SATB2 knockout mice exhibit defective epithelial repair, with a marked reduction in goblet and enteroendocrine cells.

[Journal of Cellular and Molecular Medicine] Autophagy in Caco-2 cells was induced by either rapamycin treatment or by nutrient deprivation and assessed by conventional autophagy marker proteins.

[Scientific Reports] The authors investigated bardoxolone methyl (CDDO-Me), a synthetic triterpenoid, as a potential therapeutic agent for colorectal cancer (CRC). Integrating network pharmacology, bioinformatic analyses, and in vitro assays, they evaluated the effects of CDDO-Me on CRC cells.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Researchers identified 3-aminobenzoic acid, a dietary component abundant in azuki beans, soybeans and chickpeas as a regulator of epithelial permeability and inflammation in the colon.

[PLOS One] Investigators developed and characterized a two-dimensional in vitro model of porcine colonic organoids that closely mimics native colon tissue, thereby supporting in vitro research in gastrointestinal physiology, pathology, and pharmacology.

[PLOS One] Human colon cancer cells were used to establish intestinal epithelial injury models with the urea treatment in different conditions.

[Gene] The specific biological functions and complete mechanistic understanding of miR-206 in colorectal cancer (CRC) remain largely uncharacterized. The authors provide a comprehensive analysis of miR-206′s role in CRC.

[UTR Therapeutics (Globenewswire)] UTR Therapeutics Inc. announced a new milestone, the submission of an Investigational New Drug (IND) application to the US FDA for UTRxM1-18, a novel therapeutic approach for targeting c-MYC driven cancers.

[Molecular Cancer] The authors suggested that Pioglitazone reduces prostate cancer (PCa) cell proliferation and induces metabolic and epithelial changes, highlighting the potential of repurposing metabolic drugs for PCa therapy.

[International Journal of Biological Macromolecules] Researchers investigated the roles of calcium/calmodulin-dependent serine protein kinase in prostate cancer (PCa) progression, cell migration, and invasion. They found that CASK is up-regulated in PCa tissues of patients.