[Theranostics] Scientists reviewed the studies of cartilage organoids and silk fibroin (SF)-based hydrogels. The advantages of SF-based hydrogels in constructing cartilage organoids and the iterative optimization of cartilage organoids through designing hydrogels by using artificial intelligence calculation are also discussed.

[BMC Biology] To better understand virus‒mucus layer‒intestinal epithelium interactions, here, investigators developed a porcine intestinal organoid mucus‒monolayer model under air‒liquid interface conditions.

[Cancer Science] Investigators applied a live imaging approach to organoids derived from 10 pancreatic ductal adenocarcinoma (PDAC) patients to comprehensively understand their heterogeneous growth potential and drug responses.

[Advanced Science] Researchers personalized dorsal and ventral forebrain organoids were generated derived from brain astrocytes of patients with focal cortical dysplasia type II.

[Journal of Biochemistry] Scientists suggested that targeting of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) in colorectal cancer might contribute to a new therapeutic strategy that was based on suppression of Wnt signaling and epithelial-mesenchymal transition-related cancer progression driven by cancer stem cells.

[Scientific Reports] Investigators found that IL-10 was up-regulated in CSC. IL-10 enhanced the self-renewal and tumorigenesis of nasopharyngeal CSC.

[Biomaterials Research] This study positioned FDPM, a magnetic-responsive biomimetic nanosystem, as a promising nanoplatform to target glioma stem cells and related tumor cells for improving the therapeutic effect of glioma.

[Journal of Orthopaedic Research] Scientists suggested that Msx1 modification enhances BMSC-mediated repair by promoting cell proliferation and migration, facilitating tendon-bone integration.

[Tissue Engineering Part A] Researchers demonstrated that PHBVHHx-COL scaffolds loaded with peripheral blood-derived MSCs significantly promoted the repair of cartilage injury through immune regulation by M2 polarization and could be potential candidates for cartilage tissue engineering.

[Advanced Healthcare Materials] A fully degradable mesh is designed for the treatment of pelvic organ prolapse, utilizing MSCs stimulated by a galvanic battery-powered electric field.

[Advanced Materials] Researchers discuss innovative engineering strategies offer the potential to revolutionize the next generation of CAR-T therapy, ultimately paving the way for more effective treatments in solid tumors.

[Experimental Neurology] The authors provided a comprehensive overview of stem cell therapies available to stroke patients, focusing on the different types and doses of stem cells, timing and route of administration, patient selection, clinical outcomes, translational challenges, and future directions for the field.