[Endocrine-Related Cancer] The authors take a broad view of both prostate epithelial cell-intrinsic and cell-extrinsic factors that change with age and are likely to contribute to age-related risk of prostate tumorigenesis. For each factor, they discuss the impact of these age-related changes on cancer risk.

[Oncoimmunology] Using scRNA-sequencing and multiparametric flow-cytometry analysis, researchers comprehensively characterized immune cells in wild-type and PTEN^(i)pe−/− mouse prostates, a model that closely recapitulates human prostate cancer.

[The Prostate] Researchers demonstrated that androgen deprivation therapy (ADT) induces macrophage migration inhibitory factor (MIF) upregulation, which in turn drives prostate cancer cell proliferation via upregulating AMPD2 expression, eventually contributing to the development of resistance to ADT.

[Allergy] Researchers reported the distinct effects of IL-4, IL-13, and IL-22 on bio-stabilized human skin with intact barriers and immune cells.

[Journal of Translational Medicine] Single-cell sequencing, spatial transcriptomics, and bulk RNA sequencing datasets were used to explore the changes in microenvironmental components and transcriptional programs of tumor cells during the progression of breast ductal carcinoma.

[Experimental & Molecular Medicine] Researchers utilized a Phodopus roborovskii hamster model to investigate the long-term effects of SARS-CoV-2 infection compared with influenza A virus.

[Proceedings of the National Academy of Sciences of the United States of America] Targeting Wnt signaling using a porcupine inhibitor WNT974 alleviates immune suppression in a stem cell–rich, anti-programmed cell death protein 1 (αPD1)-resistant murine glioblastoma model in the orthotopic setting and improves survival in combination with αPD1 treatment by remodeling the tumor microenvironment from protumorigenic to antitumorigenic.

[Archives of Pharmacal Research] The authors provide a comprehensive overview of recent advances in the mechanistic insights, clinical applications, and drug delivery strategies of curcumin in inflammatory bowel disease therapy, to support future research and clinical translation.

[Nature Reviews Materials] The authors thoroughly examine the structure and function of airway mucus, along with the challenges and opportunities it presents for inhaled treatments.

[Trethera Corporation] Trethera Corporation announced that the National Institutes of Health awarded Trethera a $1.8 million grant for preclinical studies of TRE-515 as a Crohn’s disease treatment.

[Nature Communications] Scientists showed with genetic approaches that a small subpopulation of endothelial cells inside the intestinal villi of the embryonic mouse gives rise to arterial endothelium in the intestinal wall but also in the distant mesenteric vasculature.

[Cell Reports] Using lineage tracing of embryonic endothelial progenitor cells and mature, adult endothelial cells, we show that a selected subset of endothelial progenitor cells can transform into rhabdomyosarcoma.