[Journal of Experimental Medicine] Researchers used organ clearing, high-resolution three-dimensional imaging, cell type–specific mouse genetics, and surgical approaches to investigate skull vasculatures.

[Cell Reports] The authors investigated alphavirus-blood-brain barrier interactions by pairing a physiologically relevant, hPSC-derived model of brain microvascular endothelial-like cells with sindbis virus strains of opposite neuroinvasiveness.

[Nature Cell Biology] Investigators showed that various transposable element families, notably LTR7, undergo transcriptomic, epigenetic and three-dimensional genome changes in response to matrix mechanical cues in hESCs.

[Stem Cell Reports] Investigators have established NANOG-reporter canine iPSC (ciPSC) lines and found that fibroblast growth factor, activin/transforming growth factor-β, and WNT signals were critical for the robust maintenance of ciPSCs.

[Science Advances] Scientists found that energetically subminimal amounts of glucose can support ongoing segmentation clock activity, providing evidence that glycolysis exerts a signaling function.

[Oncogene] Scientists utilized single-cell RNA sequencing, spatial transcriptomics, and a combination of in vivo and in vitro models to decode the dynamics of tumor-stroma interactions during human LUAD progression.

[Pediatric Research] Newborn mice were exposed to either hyperoxia or room air shortly after birth and treated subcutaneously with betaine daily for 14 days.

[Molecular Therapy] Scientists focus on gene therapy and mRNA drug approaches for nuclear-encoded gene defects causing isolated, combined, or multiple oxidative phosphorylation defects and mitochondrial-encoded gene defects for which a gene replacement approach has been tested, and on the allotopic expression of mtDNA genes.

[Cell Reports] The authors showed that during the endothelial-to-hematopoietic transition in the mouse embryo, dynamic changes in mitochondrial activity drive the production of hematopoietic stem and progenitor cells with differing potencies.

[Cell Reports Medicine] Investigators developed FL-Fc-DM1, a FLT3-targeted conjugate linking FLT3 ligand-Fc to DM1. FL-Fc-DM1 demonstrates potent anti-leukemic activity in vitro, ex vivo, and in both cell line- and patient-derived xenograft models.

[Journal of Cell Science] Scientists discovered that genes involved in cell motility, cell division, and mitotic pathways are all directly regulated by erythroid Krüppel like factor (EKLF/ KLF1).

[Experimental Hematology] Researchers leveraged single-cell transcriptomics to characterize cell states across the hematopoietic stem and progenitor (HSPC)-myeloid differentiation landscape in lower-risk myelodysplastic syndromes (MDS).