[Aging] Giant salamander skin mucus gel dressing wrapped with bone marrow mesenchymal stem cells was prepared and validated, and skin wound injury of rabbit and mouse models were established.

[Cell Death & Differentiation] Scientists demonstrated that BTG3 levels were downregulated in basal cell carcinoma and squamous cell carcinoma compared to normal skin tissue, and Btg3 knockout in mice augmented the development of papilloma in a mouse model of skin carcinogenesis.

[Journal Of Experimental & Clinical Cancer Research] Researchers identified a potent and selective inhibitor of C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) active in cellular and melanoma animal models.

[Cancer Gene Therapy] Investigators reported that TRIM58 was underexpressed in TNBC tissues and cells compared to adjacent mucosa tissue, and its downregulation was significantly associated with shorter survival.

[Molecular Cancer] The participation of histone lactylation in the growth and progression of PDAC was confirmed through inhibition of histone lactylation by glycolysis inhibitors or lactate dehydrogenase A knockdown both in vitro and in vivo.

[Weill Cornell Medicine] Dr. Timothy Ryan, professor of biochemistry in anesthesiology at Weill Cornell Medicine, has been elected to the National Academy of Sciences, one of the highest honors a scientist can receive.

[Communications Biology] Investigators demonstrated Midkine mainly expressed by CD31 + ACTA2+ECs going through partial EndMT contributed greatly to myofibroblasts by spatial and single-cell transcriptomics.

[Journal Of Anatomy] Scientists investigated whether different training histories of horses would influence the synthesis of collagen and other matrix proteins and alter the mechanical properties of tendon.

[Small] By combining collagen I and alginate, researchers designed an in vitro biomimetic hydrogel platform to independently modulate matrix stiffness and structure across a physiological stiffness spectrum while preserving consistent collagen concentration and fiber topography.

[Cell Stem Cell] Researchers found that neurons expressing SATB2, a determinant of callosal projection neuron (CPN) identity, show impaired maturation in ARID1B+/− neural organoids.

[Nature Cell Biology] Investigators implemented whole-tissue lineage tracing by genomic DNA barcoding in 3D human cerebral organoids, to show that individual stem cell clones produced progeny on a vastly variable scale.

[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, investigators identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.