[Clinical Cancer Research] The anti-multiple myeloma (MM) activity of teclistamab and talquetamab was evaluated in bone marrow (BM) samples from MM patients. T cell phenotype and function were assessed in BM/peripheral blood samples obtained from MM patients who were treated with these bispecific antibodies.

[Journal Of Biological Chemistry] Scientists reported the development of polymer-based anti-human PD-L1 antibody mimetics by attaching the macrocyclic peptide WL12 to a N-(2-hydroxypropyl)methacrylamide copolymer.

[Microbiology Spectrum] Investigators examined a panel of intravenous immunoglobulins manufactured over the past two decades for their capacity to neutralize or enhance Zika virus infection in vitro.

[Scientific Reports] Researchers evaluated the involvement of immunoglobulins and immune complexes in the occurrence of acute kidney injury in visceral leishmaniasis (VL) patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment.

[Gene Therapy] Koala Retrovirus-based envelope demonstrated remarkable efficiency in transducing freshly isolated primary human NK cells directly from blood, as well as freshly obtained monocytes, which were differentiated to M1 macrophages as well as B cells from multiple donors, achieving up to 80% reporter gene expression within three days post-transduction.

[Advanced Drug Delivery Reviews] The authors highlight recent pre-clinical and clinical advances in biomaterial-based approaches to target and modulate skin immune signaling at the tissue, cellular, and molecular levels for immunotherapeutic applications.

[Alvotech] Alvotech disclosed that under the recently announced US strategic partnership agreement, Alvotech will manufacture its high-concentration interchangeable biosimilar to Humira® for Quallent Pharmaceuticals, in alignment with its US commercialization agreement with Teva.

[Nature Communications] Researchers showed that glucocorticoid receptor (GR) and the lysine-specific demethylase 1 (LSD1) interact in myofibers of male mice, and that LSD1 connected GR-bound enhancers with NRF1-associated promoters to stimulate target gene expression.

[Cell Reports] In Max41 transgenic mice, nearly all B cells diverted into the granulocyte lineage. Investigators showed that these mice had an excess of myeloid progenitors, but their common lymphoid progenitor compartment was ablated, and they had few plasmacytoid dendritic cells.

[Journal of Leukocyte Biology] The authors discuss the molecular machinery within the noncanonical NF-κB pathway, crosstalk with the canonical NF-κB pathway, murine models of noncanonical signaling, as well as how aberrations in this pathway manifest in leukemic or hyperinflammatory disease with a focus on Hypereosinophilic syndrome.

[Indiana University School of Medicine (EurekAlert)] A new four-year, $2.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases will support the project, “Hypoxia's role in regulating stressed hematopoietic stem cells,” led byIndiana University School of Medicine scientists.

[Heliyon] The expression of homeobox gene B5 (HOXB5) in human osteosarcoma tissues and its correlation with clinical indicators were investigated using bioinformatics analysis and immunohistochemical labelling.