Keep Current with the Latest in Cell Biology Research
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Reversal of C9orf72 Mutation-Induced Transcriptional Dysregulation and Pathology in Cultured Human Neurons by Allele-Specific Excision
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators generated five different genomic excisions at the C9orf72 locus in a patient-derived iPSC line and a non-diseased wild-type line, and examined gene expression and pathological hallmarks of C9 frontotemporal dementia/ALS in motor neurons differentiated from these lines.
Nose-to-Brain Selective Drug Delivery to Glioma via Ferritin-Based Nanovectors Reduces Tumor Growth and Improves Survival Rate
[Cell Death & Disease] The authors demonstrated that a nanocarrier, named The-0504, could cross the blood-brain barrier and specifically deliver the payload to gliomas that express high amounts of the ferritin/transferrin receptor TfR1 (CD71).
The Autism Susceptibility Kinase, TAOK2, Phosphorylates eEF2 and Modulates Translation
[Science Advances] Scientists used proteomics, genetics, and translation assays in cultured cells and mouse brains to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 deletion models.
Rebound Growth of BRAF Mutant Pediatric Glioma Cells after MAPKi Withdrawal is Associated with MAPK Reactivation and Secretion of Microglia-Recruiting Cytokines
[Journal Of Neuro-Oncology] Four patient-derived pediatric glioma models were investigated to model rebound growth in vitro based on viable cell counts in response to mitogen-activated protein kinase (MAPK) inhibitor (MAPKi) treatment and withdrawal.
Infection with SARS-CoV-2 Can Cause Pancreatic Impairment
[Signal Transduction And Targeted Therapy] Scientists analyzed pancreatic lesions in autopsy tissues from SARS-CoV-2 infected non-human primates (NHPs) models and vaccinated and infected NHPs from 2020 to 2023.
A 3D Atlas of the Human Developing Pancreas to Explore Progenitor Proliferation and Differentiation
[Diabetologia] Scientists mapped the spatial and chronological dynamics of human pancreatic cell differentiation and proliferation by using 3D imaging of cleared human embryonic and fetal pancreases.
Exosomes Derived from Mesenchymal Stem Cells in Diabetes and Diabetic Complications
[Cell Death & Disease] The authors outline the properties of mesenchymal stromal cell-derived exosomes, and provide a thorough summary of their biological functions and potential uses in diabetes and its related complications.
Canada Likely to Miss WHO’s Hepatitis C Elimination Target, Research Shows
[University of Waterloo] Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.
Inflammation and Cytomegalovirus Viremia during Pregnancy Drive Sex-Differentiated Differences in Mortality and Immune Development in HIV-Exposed Infants
[Nature Communications] In a secondary analysis of the SHINE trial in rural Zimbabwe researchers explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.
Physiological DNA Damage Promotes Functional Endoreplication of Mammary Gland Alveolar Cells During Lactation
[Nature Communications] Researchers showed that DNA damage accumulates due to replication stress during pregnancy, activating the DNA damage response. Modulation of DNA damage levels in vivo by intraductal injections of nucleosides or DNA damaging agents reveals that the degree of DNA damage accumulated during pregnancy governs endoreplication and milk production.
Epigenetic Deregulation in Breast Cancer Microenvironment: Implications for Tumor Progression and Therapeutic Strategies
[Biomedicine & Pharmacotherapy] Scientists delve into the complex connections between breast cancer treatment response, underlying epigenetic changes, and vital interactions within the tumor microenvironment.
CDK7 in Breast Cancer: Mechanisms of Action and Therapeutic Potential
[Cell Communication And Signaling] Scientists delineated the biological roles of CDK7 and explicates the molecular pathways through which CDK7 exacerbates the oncogenic progression of breast cancer.