[National Institutes of Health] The Complement Animal Research In Experimentation Challenge Prize competition offered $1,000,000 in total prize money to diverse teams with ideas for new ways of using New Approach Methodologies to conduct basic research, uncover disease mechanisms, and translate knowledge into products and practice.

[Nature Reviews Immunology] The authors described the contribution of the various atypical chemokine receptors to innate and adaptive immune responses, focussing specifically on recent progress.

[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, researchers identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.

[Emerging Microbes & Infections] Investigators elucidated the antigenic characteristics and immune evasion capability of BA.2.87.1. Our findings revealed that BA.2.87.1 was more susceptible to XBB-induced humoral immunity compared to JN.1.

[Nature] The authors showed that their computationally redesigned antibody, 2130-1-0114-112, simultaneously increased neutralization potency against Delta and subsequent variants of concern, and provides protection in vivo against the strains tested: WA1/2020, BA.1.1 and BA.5.

[Acta Neuropathologica Communications] Using semiquantitative measurements of immunohistochemical signals, we examined olfactory bulbs and olfactory tract specimens collected serially at autopsies between 2020 and 2023.

[STAT News] A new study looking at the distribution of receptors that flu viruses can attach to in different cow tissues may help to explain the pattern of illness being seen in the outbreak of H5N1 bird flu in US dairy cattle — and also is sparking debate about the implications of the cow outbreak for human disease.

[CBC] A new $15-million cross-border research project is underway to monitor the movement of pathogens in Canada and the US in the event of future pandemics.

[Microbiology Spectrum] The authors designed a peptide vaccine using immunoinformatics tools, which have the potential to activate human immunity against variola virus infection efficiently. The design of peptides derives from vaccine-candidate proteins showing protective potential in vaccinia WR strains.

[Retrovirology] Researchers utilized exogenous injection of the human recombinant FMS-like tyrosine kinase 3 ligand into the hematopoietic stem cell cord blood human immune system mouse model to significantly expand the total area of lymph node and the number of circulating human T cells.

[Nature Communications] Investigators performed a systematic search and meta-analysis of the available data to test whether vaccinia-binding ELISA endpoint titer is predictive of vaccine effectiveness against mpox.

[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists discuss the state of the art of CSC biology and their potential exploitation as therapeutic target in uveal melanoma.