[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.

[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.

[Journal of Cellular and Molecular Medicine] Researchers investigated whether lncRNA MIR155HG could improve the efficacy of MSCs in the treatment of intimal hyperplasia and to elucidate the role of the competing endogenous RNA (ceRNA).

[Stem Cell Research & Therapy] Endometrial injury in intrauterine adhesion mouse model was conducted by uterine curettage and LPS injection surgery and the samples were collected at different times to detect the changes of large peritoneal macrophages and ferroptotic monocytes/macrophages.

[Jama Oncology] In this cohort study, DNA sequencing was performed on first CR blood from patients with FLT3-internal tandem duplication AML transplanted from March 2013 to February 2019.

[Cellular Signalling] The authors reported that circNCX1, the most abundant circular RNA in mammalian hearts, could affect the proliferation of murine cardiomyocytes.

[Circulation Research] Genome-wide RNA sequencing analysis was performed on the aorta isolated from saline or angiotensin II–induced abdominal aortic aneurysm (AAA) mice, and activating transcription factor (ATF) 3 was identified as the potential key gene for AAA development.

[Basic Research In Cardiology] Investigators provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure.

[Stem Cell Research & Therapy] Differentiation of kidney organoids from human iPSCs was performed. Cell survival and autophagy were analyzed using cell counting kit 8 kit and autophagy detection kit.

[Nature Cell Biology] Scientists found that ETS variant transcription factor 4 (ETV4) served as a molecular transducer that linked mechanical microenvironments and gene expression.

[Nature Communications] The authors integrated studies in patient-derived and immunocompetent lung cancer models and clinical specimens obtained from patients on targeted therapy to uncover a focal adhesion kinase-YAP signaling axis that promotes residual disease during oncogenic EGFR-, ALK-, and KRAS-targeted therapies.