[Science] Investigators reported a 3D architected electronic skin with force and strain sensing components arranged in a 3D layout that mimicked that of Merkel cells and Ruffini endings in human skin.

[Clinical Cancer Research] Scientists used biochemical and intracellular target engagement assays to demonstrate the mechanism of action of vepdegestrant, and ESR1 wild-type and mutant ER+ preclinical breast cancer models to demonstrate ER degradation-mediated tumor growth inhibition.

[Nature Communications] Scientists examined the effect of palmitoylation on pancreatic cancer progression and discovered that ZDHHC20, upregulated by KRAS, was abnormally overexpressed and associated with poor prognosis in patients with pancreatic cancer.

[Nucleic Acids Research] Investigators discovered that the histone demethylase PHF2 associated with RAD21, a core subunit of cohesin, to regulate DNA replication in mouse neural stem cells.

[Genome Medicine] Researchers screened ID cohorts for individuals with predicted-to-be damaging variants in AFF3. They used both animal and cellular models to assess the deleteriousness of the identified variants.

[JCI Insight] The authors analyzed matched primary and recurrent GBM archival tumor tissues with imaging-based techniques aimed to simultaneously evaluate tumor tissues for presence of hypoxic, angiogenic, and inflammatory niches, extracellular matrix organization, TERT promoter mutational status, and several oncogenic amplifications on the same slide and location.

[Autophagy] Investigators performed a CRISPR activation screen targeting human genes encoding membrane-associated proteins, revealing TMX2 as a potential driver of HCC cell viability.

[Current Medical Science] The authors designed a KLF4 lentiviral vector and a KLF4 siRNA lentiviral vector, to upregulate and silence KLF4 expression in human HSC LX-2 cells via transfection. Cell proliferation was assessed using the CCK-8 assay.

[Clinical and Translational Oncology] The analysis revealed different subtypes of HCC associated with cirrhosis and identified several key genes, including CCNB2, MCM4, and CDC20, with strong binding power and prognostic value.

[Therapeutic Advances In Gastroenterology] Scientists evaluated the role of rifaximin in preventing frequent cirrhosis-related infection, Clostridioides difficile infection, and all-cause mortality, as well as determining adverse effects and adherence to the drug.

[Nature Communications] Researchers determined if NLP, like NESF-1, regulated lipid accumulation in vitro, and tested if the disruption of nucb1 gene affects hepatic lipid metabolism genes in mice.

[Biomarker Research] Scientists provide an overview of the structure and roles of FGL1 and FGL2 in different liver conditions, emphasizing the intricate molecular regulatory processes and advancements in targeted therapies.