[Nature] The authors established that the presence of diverse priming events in the normal mouse intestinal epithelium can change the transformation and clonal-selection landscape, permitting the fixation of strong driver mutations in Apc and Ctnnb1 that are otherwise lost due to negative selection.

[Nature Communications] Scientists showed that cellular redox balance orchestrates niche factors with metabolic state to govern cell fate decisions.

[Nature Aging] By analyzing DNA methylation and gene expression data from healthy and cancerous human colon samples, investigators identified an aging and colon cancer-associated DNA methylation drift.

[Experimental & Molecular Medicine] The authors identified increased heterogeneous nuclear ribonucleoprotein U (HnRNPU) expression in patients with colon adenocarcinoma, with higher levels correlating with poor patient survival.

[Oncogene] Researchers identified that TATA-binding protein-associated factor-1 (TAF1), also as a lysine acetyltransferase, is frequently upregulated in colorectal cancer.

[Communications Biology] Scientists showed that protein Kinase A (PKA) is central to a signaling cascade involving the G protein-coupled estrogen receptor GPER1, which is essential for centrosome integrity in colon cancer cells.

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors dissect the “yin-yang” of BRAF as a therapeutic vulnerability in in melanoma and colorectal cancer and underscore the critical importance of tumor-specific context in precision oncology.

[Karolinska Institute] One of the young researchers receiving Knut and Alice Wallenberg Foundation’s basic research grant this year is Camilla Engblom. She will use the funding to study a piece of the puzzle that could help develop more precise and personalized treatments for cancer and inflammatory bowel disease.

[Cell Death & Disease] Researchers elucidated gas plasma-induced bacterial pathogen-associated molecular patterns (PAMP) release and their combination with direct gas plasma exposure in skin cancer cells in vitro.

[PLoS Genetics] Scientists identified melanoma-associated lncRNAs predicted to be components of the MITF gene regulatory network in human melanoma that have positionally equivalent transcripts in zebrafish.

[Molecular Oncology] The authors dissected signaling and mitochondrial alterations that characterize the transition from BRAF-specific inhibitors responsiveness to resistance in A375 melanoma cells.

[Journal of Translational Medicine] Researchers demonstrated that glutathione peroxidase 8 (GPX8) is a critical oncogene in osteosarcoma progression and that its expression is regulated by kruppel‑like factor 16 (KLF16).