[Biomaterials Research] The authors revealed that exosomes derived from human hair follicle mesenchymal stem cells effectively enhanced the migration and proliferation of human dermal fibroblasts (HDFs) and upregulated the expressions of TGF-β1, p-Smad2/p-Smad3, collagen type 1, and collagen type 3.

[Nature Communications] Using the most prevalent retinoic acid receptor gamma (RARG) fusion, CPSF6-RARG (CR), as a representative, scientists revealed that the CR fusion, enhanced the expansion of myeloid progenitors, impaired their maturation and synergized with RAS mutations to drive more aggressive myeloid malignancies.

[Science Advances] Researchers examined whole-body ceramide synthase 2 (Cers2) knockout and rs267738 knock-in mice. Both models exhibited glucose intolerance and impaired insulin secretion in vivo. Islets isolated from these models also demonstrated reduced β cell function, as shown by decreased insulin secretion ex vivo.

[Nature Communications] Scientists showed that RARG fusions disrupted myeloid differentiation and promoted proliferation and self-renewal of hematopoietic stem and progenitor cells by upregulating BCL2 and ATF3.

[Metabolism Clinical and Experimental] Investigators applied biochemical studies, qPCR, proteomics, and immuno-confocal microscopy to determine the underlying protective mechanisms of double C 2 like domain beta (DOC2b) in β-cells.

[Journal of Experimental & Clinical Cancer Research] Researchers investigated the antileukemic activity and underlying molecular mechanism of the combination of ONC213 + venetoclax against AML cells. They reported that ONC213 could resensitize venetoclax + azacitidine-resistant AML cells to venetoclax therapy and target leukemia stem cells ex vivo and in vivo.

[Cell Stem Cell] Researchers developed a high-fidelity blastoid model using four chemicals + leukemia inhibitory factor naive human pluripotent stem cells. By extending the 3D culture to 14 days, these blastoids mimicked early gastrulation, demonstrating the specification and migration of cells.

[Molecular Therapy] Researchers detected KRASG12D protein in cancer-associated fibroblasts (CAFs) from clinical samples of PDAC. In vitro experiments demonstrated that KRASG12D protein in CAFs was not expressed from its own mutant gene but was derived from the ingestion of tumor cell-derived extracellular vesicles.

[Cell Reports] Researchers showed the role of Miro1 in horizontal mitochondrial transfer in mouse melanoma models in vivo and its involvement with tunneling nanotubes.

[Journal of Hematology & Oncology] The authors scrutinize the key players in the tumor microenvironment (TME) and the TME's contribution to epithelial-mesenchymal transition, emphasizing avenues to therapeutically disrupt the interactions between the various TME components.

Bmi-1 regulates self-renewal, proliferation, and differentiation of GBM cells, promoting stemness and therapy resistance. The authors discuss the importance of targeting Bmi-1 which could...

Eterna Therapeutics announced positive results from a preclinical study on the company’s lead cell therapy product, ERNA-101, which is designed to activate and regulate...