[International Immunopharmacology] Scientists elucidated the molecular mechanisms underlying perillaldehyde-mediated endothelial protection through the establishment of endothelium-specific TRPM2 transgenic and knockout murine models.

[Molecular and Cellular Biochemistry] The authors synthesize currently available in vitro models regarding endothelial cell dysfunction, emphasizing cardiovascular diseases. They focused on 2D cell culture models, 3D cell culture systems, and models.

[EYLEA HD® (aflibercept) Injection 8 mg sBLA Accepted for FDA Priority Review for Both the Treatment of Macular Edema Following Retinal Vein Occlusion (RVO) and for Monthly Dosing in Approved Indications] Regeneron Pharmaceuticals, Inc. announced that the US FDA accepted for Priority Review the supplemental Biologics License Application (sBLA) for EYLEA HD^® Injection 8 mg. The sBLA seeks approval for EYLEA HD for both the treatment of macular edema following RVO, and for broadening the dosing schedule to include monthly dosing across approved indications.

[Cardiovascular Diabetology] Cardiomyocyte-specific NHE1 ablation or pharmacological inhibition worsened cardiac dysfunction and fibrosis in MI with acute hyperglycemia, while NHE1 overexpression conferred protection.

[Aging Cell] The authors aimed to understand how aging impacts mitochondrial 3D structure and its regulators in skeletal muscle. They hypothesized that aging led to remodeling of mitochondrial 3D architecture permissive to dysfunction and was ameliorated by exercise.

[Advanced Science] Investigators defined the role of CCDC80 in the formation and development of aortic dissection (AD). Significant downregulation of CCDC80 in vascular smooth muscle cell in human and mouse AD was identified.

[Kaohsiung Journal of Medical Sciences] Researchers explored the differential expression of lncRNA PVT1 in intracranial aneurysms and its role in the phenotypic switching of vascular smooth muscle cells.

[Biogerontology] The authors explore the most recent discoveries regarding the role of senescent cell accumulation and calcium signalling perturbances in cardiac aging.

[Italfarmaco S.p.A. (BioSpace)] Italfarmaco S.p.A. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending the granting of a conditional marketing authorization for Duvyzat^®, a novel histone deacetylase inhibitor. The authorization is for the treatment of patients with Duchenne muscular dystrophy aged six years and older who are able to walk, when taken together with corticosteroids.

[FASEB Journal] Scientists observed that among compounds related to protein homeostasis, the valosin-containing protein (VCP) inhibitor CB-5083 demonstrated the most significant variation in sensitivity among NSCLC cells, categorized according to FAT atypical cadherin 1 (FAT1) expression levels.

[PLOS One] Scientists investigated SLC2A2’s role in liver differentiation using in silico, in vitro, and in vivo approaches.

[Cellular and Molecular Life Sciences] Researchers demonstrated that the MIR670 host gene (MIR670HG) significantly suppressed tumor liver metastasis by enhancing phagocytosis of various tumor cells by Kupffer cells.